Essay/Term paper: Huntington's disease

Essay, term paper, research paper:  Medicine

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Huntington's Disease


Huntington's disease, or Huntngton's chorea, is a genetic disease that
causes selective neural cell death, which results in chorea, or irregular,
jerking movements of the limbs caused by involuntary muscle contractions, and
dementia. It can cause a lack of concentration and depression. It also may
cause atrophy of the caudate nucleus, a part of the brain. However, symptoms
vary between individuals, with some sufferers showing symptoms that others do
not. Those suffering from Huntington's disease normally begin displaying
symptoms between the ages of 30 and 50, but has been known to show itself in
people as young as two and as old as 80.
Huntington's disease is inehrited from one of the victim's parents.
Since the gene for HD is dominant, there is a 50% chance of a sufferer's
offspring inheriting the disease. Because a victim usually does not begin to
display symptoms until after the period in which he or she would have children
and the disease may have been misdiagnosed in earlier generations as Parkinson's
disease or other similar affliction, he or she might pass along the gene without
even knowing it.
The gene for Huntington's disease is located on the short arm of
chromosome four in cytogenetic band 4p16.3. It was first identified in 1993.
While everyone posseses this gene, in someone suffering from Huntington's
disease, the number of repeats of a certain trinucleotide, cytozine-adenine-
guanine (CAG), is much larger than what it is in a normal person. In an average
person, the number of repeats is between 9 and 37. But is a sufferer of HD, the
repeat count is from 37 to 86. While nobody has found a direct correlation
between the number of repeats and the age when symptoms appear, there is
evidence that people with very high numbers of repeats contract the rarer early-
onset Huntington's disease, which usually affects people under the age of 20.
It is estimated that between .1 and 10 % of people who suffer from Huntington's
disease have obtained it through new mutations.
There are three different tests for Huntington's disease. The first,
presymptomatic testing, is for people who are at risk for the disease. The
second, prenatal testing, is a testing of a fetus at risk for the disease. The
third type of testing, confirmatory testing, is used on someone suspected of
having Huntington's disease.
Treatment of Huntington's disease usually involves counciling and
education about the disease of both the family and the patient. Since the
symptoms are so varied in both type and severeness from patient to patient,
medical treatment must be individualized.
Depression, a common symptom, is usually treated with tricyclic
antidepressants. Those that also show obsessive compulsive behavior may take
some types of serotonergic agents.
Neuroleptics, or drugs that block dopamine receptors, are useful in the
treatment of chorea.
It has been suggested that treatment with nerve-growth producing agents
may be an affective treatment, but research is still being conducted.
Procedures such as pallidotomy, or removing part of the globus pallidus, and
thalamotomy, or cutting part of the thalamus have both showed promising results
in the treatment of the involuntary movements and tremors in Parkinson's disease
and may also help sufferers of Huntington's. Fetal brain tissue transplantation
has also helped in Parkinson's disease patients. While there has been a few of
these transplantations performed on HD patients, it is still too early to
evaluate its success.
Since the huntington protien causes a gain of function instead of a loss
of function, normal gene therapy tecniques normally do not work. Instead, the
protien must be removed or its gain of function effects must be inhibited.
Currently, the second approach makes more sense, since we already know how the
huntington protein interacts with other proteins and we can, through this
knowledge, find modulators to treat the disease.
In conclusion, Huntington's disease is a degenerative disease of the
mind and body. It ultimately causes death. While current treatments can only
help the symptoms, it is hoped that further research and new tecniques will
bring about an effective cure.

Web Sites Used

Baylor College of Medicine- Information on Huntington's Disease
http://www.bcm.tmc.edu/neurol/struct/hunting/hunt6.html Huntington's Disease
Society of America- Northeast Ohio Chapter http://lkwdpl.org/hdsahome.htm

Huntington's Disease Information http://www.lib.uchicago.edu/~rd13/hd/

Caring for People With Huntington's Disease
http://www.kumc.edu/hospital/huntingtons

 

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